Important discoveries highlight the functions of important genes identified by gene ontology and pathway enrichment studies linked to p53 signaling, mitophagy, and protein degradation pathways, such as Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Zeng et al., 2025)
These observations underscore a crucial point: the complications are closely linked to the immune system, and the regeneration of TMI relies heavily on the inflammatory processes during this phase (91)
doi: 10.1038/jhg.2014.10 71
Dysregulated pathways such as PI3K/AKT, 58 MAPK, 59 NF-B, and Wnt 60 not only promote tumor cell survival and proliferation but also modulate drug metabolism, DNA repair, and apoptotic thresholds